Tatsuo Kawai (Massachusetts General Hospital / Harvard Medical School)

2023- Director, Legorreta Center for Clinical Transplant Tolerance, MGH

2015 - Professor of Surgery, Harvard Medical School, Boston, MA

2012 - A. Benedict Cosimi Chair, Transplant Surgery, Massachusetts General Hospital, Boston, MA

2008 - 2014 Associate Professor of Surgery, Harvard Medical School, Boston, MA

1981 MD Nihon University School of Medicine

Immunological tolerance

Xenotransplantation

Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey B, Ko DS, Hertl M, Goes NB, Wong W, Williams WW Jr, Colvin RB, Sykes M, Sachs DH. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008 Jan 24;358(4):353-61.

Kawai T, Sachs DH, Sykes M, Cosimi AB. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2013 May 9;368(19):1850-2.

Sasaki H, Hirose T, Cippà P, Fehr T and Kawai T. Selective Bcl-2 inhibition promotes hematopoietic chimerism and renal allograft tolerance without myelosuppression in nonhuman primates. 2023, Sci Transl Med 5;15(690)

Design and testing of a humanized porcine donor for xenotransplantation. Anand RP, Layer JV, Heja D, Hirose T, , Kawai T*, Youd ME*, Qin W*. Nature. 2023 Oct;622(7982):393-401. *supervised the study equally.

Kawai T, Williams WW, Elias N et al. Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease. N Engl J Med. 2025 May 15;392(19):1933-1940.