Hyun Je Kim (Seoul National University Hospital)

09/2025- Assistant Professor, School of Transdisciplinary Innovations, Seoul National University, Seoul, Republic of Korea

04/2023- Assistant Professor, Interdisciplinary Program in Artificial Intelligence, Seoul National University, Seoul, Republic of Korea

03/2023- Assistant Professor, Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea

03/2012-02/2017 PhD, Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea

03/2001-02/2007 MD, Seoul National University College of Medicine (Honors Graduation), Seoul National University, Seoul, Republic of Korea

1. Human Disease Stratification via Multi-Omics
Integration of advanced multi-omics platforms with immunological frameworks to refine molecular classification of autoimmune diseases and cancers, with the goal of enabling precision therapeutic development.

2. Regulatory T Cell (Treg) Biology and Dysfunction
Investigation of Treg-mediated immune regulation in inflammatory and tumor microenvironments, focusing on mechanisms of immune tolerance, dysfunction, and their contribution to disease progression.

3. Immune Mechanisms in Inflammation and Cancer
Dissection of cellular and molecular immune networks within diseased tissues to identify key pathways driving pathology and potential targets for therapeutic intervention.

4. Translational Immunology and Therapeutic Target Discovery
Identification of actionable immune targets to restore immune homeostasis and develop novel immunomodulatory therapies.

5. Single-Cell and Spatial Immunoprofiling Technologies
Application of high-dimensional platforms, including CyTOF, Olink proteomics, single-cell RNA-seq, scATAC-seq, scTCR/BCR-seq, and spatial transcriptomics (Slide-seq, NanoString GeoMx/CosMx, 10x Visium), to characterize immune landscapes in health and disease.

1. Kwon H, Kang M, Jeong S, Chae M, Lee HS, Lee BH, Nam HJ, Park HW, Lee SY*, Kim HJ*. Single-Cell Transcriptomic Profiling Reveals a Distinct Monocyte MIF/ANXA1 Signature Associated With Poor Responsiveness to ICS. Allergy Asthma Immunol Res. 2025 Sep;17(5):658-667. doi: 10.4168/aair.2025.17.5.658. PMID: 41044838

2. Choi HS, Jung S, Kim KM, Lee M, Park JH, Hwang S, Cha SM, Young JN, Poplausky D, Nam H, Gulati N, Park CG, Kim HJ*, Park JU*. CXCL16 Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via CXCR6 Regulatory T Cell. Cancer Med. 2025 Aug;14(15):e71060. doi: 10.1002/cam4.71060. PMID: 40776410

3. Song J, Kang M, Jang Y, Joh CS, Shin HY, Baik JY, Choi HS, Kim KH, Lee SM, Cha SM, Ku H, Han A, Min SI, Ha J, Moon KC, Park S, Han SS, Lee H, Kim DK, Oh KH, Joo KW, Moon JH, Park CG, Kim YS, Yang SH*, Kim HJ*, Kim YC*. Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial transcriptomics. Sci Rep. 2025 Jul 3;15(1):23770. doi: 10.1038/s41598-025-05191-x. PMID: 40610502

4. Kang SJ, Gong JR, Jin SP, Oh JM, Jin H, Lee Y, Moon Y, Kim D, Nam HJ, Choi HS, Hwang S, Huh YJ, Han KY, Moon J, Chung J, Park WY, Park CG, Kim HJ* & Kim JE*. Deciphering Dysfunctional Regulatory T Cells in Atopic Dermatitis. Allergy. 2024 Dec 18. doi: 10.1111/all.16439. Epub ahead of print. PMID: 39692151.

5. Bang SY, Suh-Yun Joh C, Itamiya T, Jeong S, Lee JH, Kwon H, Jin H, Jung J, Chung H, Lee BH, Gong JR, Ishigaki K, Fujio K, Bae SC, Kim HJ*, Lee HS*. Unveiling the dynamics of B lymphocytes in systemic lupus erythematosus patients treated with belimumab through longitudinal single-cell RNA sequencing. Rheumatology (Oxford). 2024 Jul 22:keae364. doi: 10.1093/rheumatology/keae364. Epub ahead of print. PMID: 39037931.