Xin Sheng (Zhejiang University)

Ph.D., Bioinformatics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China (2012 - 2017). Mentor: Drs. Jun Yu and Jingfa Xiao

B.S., Bioinformatics, Harbin Medical University, Harbin, Heilongjiang Province, China (2007 - 2012).

Identifying causal genes and cell types for chronic kidney disease

1. Xin Sheng^#, Yuting Guan^#, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, Zhen Miao, Matthew J. Seasock, Matthew Palmer, Myung K. Shin, Kevin L. Duffin, Steven S. Pullen, Todd L. Edwards, Jacklyn N. Hellwege, Adriana M. Hung, Mingyao Li, Benjamin Voight, Thomas Coffman, Christopher D. Brown, Katalin Susztak. Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. Nature Genetics, doi: 10.1038/s41588-021-00909-9. Epub. (2021) (IF=36.6)

2. Xiangchen Gu^#, Hongliu Yang^#, Xin Sheng^#, Yi-An Ko, Chengxiang Qiu, Jihwan Park, Shizheng Huang, Rachel Kember, Renae L. Judy, Joseph Park, Scott M. Damrauer, Girish Nadkami, Ruth JF Loos, Vy Thi Ha My, Kumardeep Chaudhary, Erwin P Bottinger, Ishan Paranjpe, Aparna Saha, Christopher Brown, Shreeram Akilesh, Adriana M. Hung, Matthew Palmer, Aris Baras, John D. Overton, Jeffrey Reid, Marylyn Ritchie, Daniel J. Rader, Katalin Susztak. Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity. Science Translational Medicine, doi: 10.1126/scitranslmed.aaz1458. Epub. (2021) (IF=16.9)

3. Xin Sheng, Chengxiang Qiu, Hongbo Liu, Caroline Gluck, Jesse Y. Hsu, Jiang He, Chi-yuan Hsu, Daohang Sha, Matthew R. Weir, Tamara lsakova, Dominic Raj, Hernan Rincon-Choles, Harold I. Feldman, Raymond Townsend, Hongzhe Li, and Katalin Susztak. Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease. Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.2005905117. Epub. (2020) (IF=10.8)

4. Mingming Lu^#, Yanan Chu^#, Ziwei Zhu^#, Siyi Chen, Danfei Zhu, Congfan Bu, Qiheng Qian, Chen Gao, Meiye Jiang, Hao Zhang, Jinyue Wang, Jingyao Zeng, Zhewen Zhang, Qiong Zhao, Shuai Liu, Xudong Fu, Na Kong, Francis KM Chan, Yongcheng Wang, Guangyi Jiang*, Yu Kang*, Xin Sheng*. Multi-omics data integration study nominates key causal lncRNAs for high-grade serous ovarian cancer. Journal of Advanced Research 2026, epub. (IF=13)

5. Yi Chai, Ruiying Zhang, Shunze Jia, Danfei Zhu, Siyi Chen, Xudong Fu*, Xin Sheng*. Toti: an integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells. Stem Cell Reports 2025, 20(9): 102605 (IF=5.9)